The GFS model is predicting a storm system to ride the Southern US and shoot north along the East Coast, gaining strength as it does so from the Atlantic Ocean. This system would most likely be riding on an increasingly-strengthening subtropical jet stream, which does hold its domain in the Southern US and is commonly the preferred jet stream that produces Nor'easters. Global wind observations and torque anomalies tell me that this is indeed a potential significant storm system, if the energy can flow into the subtropical jet stream (STJ) and the stream can cooperate to send the system into the Northeast.
This system has been showing up for a while now, and must be watched very carefully. The presence of an enhanced subtropical jet stream and a more active period incoming as the Rex Block places low pressure in the Southwest does provide chances for possibly significant snow in the US.